Tools for protein characterization are in constant development. One of the newest and most exiting tools is the Fida 1 analyzer from Fida Biosystems, which enables measurement of both tertiary structures and binding affinities of biomolecules and multi-component complexes ranging from 0,3 to 1000 nm in size. The in-solution measurement is buffer independent and can be performed in under native conditions without any requirement for immobilization.

Our Fida 1 instrument is advancing customer's research within Conformational Changes, Oligomeric State Analysis, Membrane Proteins, Targeted Protein Degradation, Nanoparticles, Fibrils, Liquid-Liquid Phase Separations and much more.

The core measurement of the FIDA technology, or Flow-Induced-Dispersion- Analysis, is a measure of biomolecular size in nanometers. The readout is more accurate than any other biophysical technology, and can measure in crude matrices like Serum/Plasma, Cell Lysate and Fermentation Media.

Applications:
Oligomeric state
Stoichiometry
Ternary complex formation
Cooperativity
Ubiquitination
Fraction bound
Conformational changes
Multiple bindings
Immunogenicity
Quantification in complex solutions
Functional interactions
Affinity constants
Molecular size / hydrodynamic diameter (0,1-1.000 Dh)
Diffusion coefficient
Viscosity